Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 51 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Choline (from 630 mg Choline Bitartrate)
250 mg
45%
Inositol
250 mg
â€
Top Medical Research Studies
8
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Read More
7
We aimed to explore the effects of myo-inositol (MI) supplementation on oxidative stress in obese patients suffering from non-alcoholic fatty liver disease (NAFLD). In our double-blinded, placebo-controlled study, 51 newly diagnosed patients were divided into two groups—one receiving 4 grams of MI daily and the other receiving a placebo—while following dietary recommendations for an 8-week period.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some ways—like a decrease in feelings of hunger and desire for unhealthy foods—the MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some ways—like a decrease in feelings of hunger and desire for unhealthy foods—the MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
Read More
Most Useful Reviews
9
Improved liver function
95 people found this helpful
This supplement was prescribed to enhance my liver health, addressing discomfort in my right hypochondrium. Although tests were normal, there were some changes indicating liver disease. The product comprises natural ingredients, and I found it easy to take. The pain and heaviness have vanished, and my digestion has improved significantly. My follow-up tests showed stabilised indicators.
Read More
9
Helps liver disease
61 people found this helpful
This supplement is ideal for everyone, with no contraindications aside from individual intolerance. It aided my fatty liver disease and facilitated weight loss, while also regulating cholesterol levels and improving endocrine health.
Read More
9
Liver protector
47 people found this helpful
Choline is crucial for synthesising acetylcholine and contributes to liver disease protection. It lowers blood cholesterol and cleanses blood vessels, reducing cardiovascular risk. Inositol also supports brain function and can improve metabolic health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Read More
7
We aimed to explore the effects of myo-inositol (MI) supplementation on oxidative stress in obese patients suffering from non-alcoholic fatty liver disease (NAFLD). In our double-blinded, placebo-controlled study, 51 newly diagnosed patients were divided into two groups—one receiving 4 grams of MI daily and the other receiving a placebo—while following dietary recommendations for an 8-week period.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some ways—like a decrease in feelings of hunger and desire for unhealthy foods—the MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some ways—like a decrease in feelings of hunger and desire for unhealthy foods—the MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
Read More
User Reviews
USERS' SCORE
Good
Based on 51 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved liver function
95 people found this helpful
This supplement was prescribed to enhance my liver health, addressing discomfort in my right hypochondrium. Although tests were normal, there were some changes indicating liver disease. The product comprises natural ingredients, and I found it easy to take. The pain and heaviness have vanished, and my digestion has improved significantly. My follow-up tests showed stabilised indicators.
Read More
9
Helps liver disease
61 people found this helpful
This supplement is ideal for everyone, with no contraindications aside from individual intolerance. It aided my fatty liver disease and facilitated weight loss, while also regulating cholesterol levels and improving endocrine health.
Read More
9
Liver protector
47 people found this helpful
Choline is crucial for synthesising acetylcholine and contributes to liver disease protection. It lowers blood cholesterol and cleanses blood vessels, reducing cardiovascular risk. Inositol also supports brain function and can improve metabolic health.
Read More
9
Liver preparation aid
26 people found this helpful
I took this to prepare my liver for treatment and noticed an improvement in my condition, making the procedure easier than expected. I've ordered more as I was pleased with the results.
Read More
9
Improved cholesterol levels
23 people found this helpful
A healthy liver and a clear mind. Choline and inositol are vital for liver health and cholesterol metabolism. I've noticed increased mental clarity and reduced fatigue. After three months, my cholesterol levels normalised, cravings for sweets vanished, and I felt more purposeful. Choline and inositol can also benefit conditions like liver disease and support memory.
Read More
Frequently Asked Questions
7.5
Liver health improved
57 people found this helpful
After taking NOW Foods Choline and Inositol for a month, I’ve noticed increased energy and better mental performance. It seems to improve liver health, reduce cholesterol, and alleviate chronic fatigue. Overall, I feel better and recommend it, though consult a doctor first.
7.5
Liver enzyme reduction
45 people found this helpful
My husband's ALT levels were high despite normal tests until he took NOW choline and inositol for 4-5 months, which reduced his ALT from 45-50 to 38. This product finally worked for his liver disease.
9
Improved cholesterol levels
23 people found this helpful
A healthy liver and a clear mind. Choline and inositol are vital for liver health and cholesterol metabolism. I've noticed increased mental clarity and reduced fatigue. After three months, my cholesterol levels normalised, cravings for sweets vanished, and I felt more purposeful. Choline and inositol can also benefit conditions like liver disease and support memory.
9
Improved liver function
95 people found this helpful
This supplement was prescribed to enhance my liver health, addressing discomfort in my right hypochondrium. Although tests were normal, there were some changes indicating liver disease. The product comprises natural ingredients, and I found it easy to take. The pain and heaviness have vanished, and my digestion has improved significantly. My follow-up tests showed stabilised indicators.
6
Motivation boost
32 people found this helpful
This supplement, beneficial for fatty liver, greatly improves my motivation and energy. It has also reduced chronic swelling, positively impacting my sense of well-being during menopause.
9
Maintained liver health
14 people found this helpful
After being diagnosed with fatty layers in my liver, I took choline and inositol for ten years. Regular tests showed positive results, and my liver function remains stable, despite not altering my diet significantly.
9
Essential for liver function
19 people found this helpful
Choline is crucial for brain, muscle, and liver health. It prevents fat accumulation in the liver and supports intercellular membranes. I discovered that combining choline with inositol significantly enhances benefits, such as fat metabolism and nervous system support.
8
We conducted a double-blinded, placebo-controlled clinical trial to explore how myo-inositol (MI) influences insulin resistance (IR) among obese individuals with non-alcoholic fatty liver disease (NAFLD). Our study involved 48 participants who were randomly assigned to receive either 4 grams of MI or a placebo daily for eight weeks.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
Throughout this period, we measured various parameters such as weight, serum glucose levels, and insulin sensitivity indices before and after the intervention. Notably, we found that MI supplementation led to significant improvements in the expression levels of key genes related to the AMPK/PI3K/AKT signaling pathway, which plays a crucial role in regulating metabolism.
The results indicated noteworthy enhancements in insulin resistance for those who received MI, measured through multiple indices, reinforcing its potential benefits for liver health management. Thus, we observed that supplementing with myo-inositol not only bolstered the expression of important metabolic genes but also helped improve insulin resistance in our participants with NAFLD.
7
We aimed to explore the effects of myo-inositol (MI) supplementation on oxidative stress in obese patients suffering from non-alcoholic fatty liver disease (NAFLD). In our double-blinded, placebo-controlled study, 51 newly diagnosed patients were divided into two groups—one receiving 4 grams of MI daily and the other receiving a placebo—while following dietary recommendations for an 8-week period.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some ways—like a decrease in feelings of hunger and desire for unhealthy foods—the MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
At the end of the trial, we observed that both groups experienced significant reductions in body weight and other obesity measures. Interestingly, those taking MI showed a slightly larger decrease in weight, which was statistically significant. While there was no significant difference in most antioxidant levels between the two groups, we noted that the MI group did see a greater reduction in serum nitric oxide.
Although both groups benefited in some ways—like a decrease in feelings of hunger and desire for unhealthy foods—the MI group specifically showed a more pronounced reduction in the desire to eat fatty foods. Overall, MI supplementation positively influenced weight and certain oxidative stress markers, while also providing potential advantages in managing dietary cravings. However, we did not find significant changes in many of the oxidative stress biomarkers related to liver function, emphasizing that while MI appears beneficial for some aspects, more research is needed to fully understand its effects on liver health.
References
- Aghajani T, Arefhosseini S, Ebrahimi-Mameghani M, Safaralizadeh R. The effect of myo-inositol supplementation on AMPK/PI3K/AKT pathway and insulin resistance in patients with NAFLD. Food Sci Nutr. 2024;12:7177. doi:10.1002/fsn3.4267
- Rostami S, Arefhosseini S, Tutunchi H, Khoshbaten M, Ebrahimi-Mameghani M. Does myo-inositol supplementation influence oxidative stress biomarkers in patients with non-alcoholic fatty liver disease?. Food Sci Nutr. 2024;12:1279. doi:10.1002/fsn3.3842
